The Global Ascendency of OXA-48-Type Carbapenemases
نویسندگان
چکیده
منابع مشابه
OXA-48-like carbapenemases: the phantom menace.
OXA-48-type carbapenem-hydrolysing class D β-lactamases are increasingly reported in enterobacterial species. To date, six OXA-48-like variants have been identified, with OXA-48 being the most widespread. They differ by a few amino acid substitutions or deletions (one to five amino acids). The enzymes hydrolyse penicillins at a high level and carbapenems at a low level, sparing broad-spectrum c...
متن کاملNoncarbapenemase OXA-48 Variants (OXA-163 and OXA-405) Falsely Detected as Carbapenemases by the β Carba Test.
Laurent Dortet, Thierry Naas Associated French National Reference Center for Antibiotic Resistance, Le Kremlin-Bicêtre, France; Research Unit EA7361 “Structure, Dynamic, Function and Expression of Broad Spectrum β-Lactamases,” Faculty of Medicine, University Paris-Sud, Le Kremlin-Bicêtre, France; Department of Bacteriology-Parasitology-Hygiene, Bicêtre Hospital, Assistance Publique—Hôpitaux de ...
متن کاملCharacterization of Enterobacteriaceae producing OXA-48-like carbapenemases in the UK.
OBJECTIVES To characterize UK clinical isolates of Enterobacteriaceae producing OXA-48-like carbapenemases and to compare their resistance plasmids. METHODS Twenty-six enterobacteria producing OXA-48-like enzymes were studied. These were from 22 diverse hospitals in the UK. Isolates of Escherichia coli and Klebsiella pneumoniae were assigned to clonal lineages by multilocus sequence typing. C...
متن کاملOXA-type carbapenemases in Acinetobacter baumannii in South America.
Acinetobacter baumannii is an opportunistic pathogen that is frequently involved in outbreaks of infection, occurring mostly in intensive care units. The increasing incidence of carbapenem resistance in A. baumannii worldwide is a concern since it limits drastically the range of therapeutic alternatives. The most important mechanism of carbapenem resistance is the enzymatic hydrolysis mediated ...
متن کاملNew Delhi metallo-β-lactamase and OXA-48 carbapenemases in Gram-negative bacilli isolates in Libya
To the Editor Carbapenems (i.e. ertapenem, imipenem, meropenem, and doripenem) are second line antimicrobials reserved to treat serious infections, including those caused by Gramnegative bacilli (GNB) producing extended-spectrum b-lactamses (ESBLs). ESBLs mediate resistance among GNB to b-lactam drugs, including third generation cephalosporins. Emergence of carbapenemases-producing GNB (mainly ...
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ژورنال
عنوان ژورنال: Clinical Microbiology Reviews
سال: 2019
ISSN: 0893-8512,1098-6618
DOI: 10.1128/cmr.00102-19